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You are here:Home » Antibodies » Abs to Tyrosine Kinases » Anti -Brk (Protein Tyrosine Kinase 6, PTK6)

Anti -Brk (Protein Tyrosine Kinase 6, PTK6)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E
PTK6 (protein tyrosine kinase 6, BRK or FLJ42088),with 451-amino acid protein (about 51kDa), encods a cytoplasmic nonreceptor protein kinase which may function as an intracellular signal transducer in epithelial tissues. Its presence in the nucleus appears to be linked to suppression of tumor progression. The encoded protein has been shown to undergo autophosphory-lation. Very high level in colon and high levels in small intestine and prostate, and low levels in some fetal tissues. And Expressed at low level in some breast tumors, but not in normal breast. Also found in melanocytes, but not expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Overexpression of this gene in mammary epithelial cells leads to sensitization of the cells to epidermal growth factor and results in a partially transformed phenotype.
Catalog #B2765-03B
ApplicationsSuitable for use in ELISA. Other applications not tested.
Recommended DilutionELISA: 1:10,000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG2b
Clone No8J380
HostMouse
ConcentrationNot determined
FormSupplied as a liquid containing 0.03% sodium azide.
PurityPurified by Protein A affinity chromatography.
ImmunogenNi-NTA purified truncated recombinant PTK6 expressed in E. Coli strain BL21 (DE3).
SpecificityRecognizes human Brk /PTK6.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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