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You are here:Home » Antibodies » Abs to DNA Replication, Repair » Anti -BubR1 (BubR1, budding uninhibited by benzimidazoles related 1, Bub1b, budding uninhibited by benzimidazoles 1 homolog beta, MAD3L, mitotic arrest deficient-like 3)

Anti -BubR1 (BubR1, budding uninhibited by benzimidazoles related 1, Bub1b, budding
uninhibited by benzimidazoles 1 homolog beta, MAD3L, mitotic arrest deficient-like 3)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IP
Catalog #B2790-50A
BubR1 is a predicted 1050 amino acid mitotic checkpoint kinase which also controls chromosome segregation. It contains 2 domains CD1 directs kinetochore localization and binding to Bub3, and CD2 contains the kinase domain. Between CD1 and CD2, the BUB1B protein has a putative nuclear localization signal. BubR1 contains a putative cyclin destruction box that can target proteins for degradation by proteosomes during mitosis.
ApplicationsSuitable for use in Immunoprecipitation and Western Blot. Other applications have not been tested.
Recommended DilutionImmunoprecipitation: 2-5ug/mg
Western Blot: 1:2000-1:10,000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
HostRabbit
SourceHuman
Concentration~0.2mg/ml
FormSupplied as a liquid in TBS, pH 7.2, 0.1% BSA, 0.09% sodium azide.
PurityPurified by Immunoaffinity chromatography.
ImmunogenThe epitope recognized by this antibody maps to a region between residue 1 and 50 of human budding uninhibited by benzimidazoles 1 homolog beta using the numbering given in entry NP_001202.3 (GeneID 701).
SpecificityRecognizes human BubR1
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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