| FALZ/BPTF is a histone-binding component of NURF (nucleosome remodeling factor), a complex that catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. This gene was identified in brain homogenates from patients with Alzheimer's disease. Analysis of the original protein (fetal Alz-50 reactive clone 1, or FAC1), containing a DNA-binding domain, a zinc finger motif, and a C-terminal bromodomain, suggested it might play a role in the regulation of transcription during proliferation. High levels of FAC1 were detected in fetal brain and in patients with neurodegenerative diseases. This protein is highly similar to the largest subunit of the Drosophila NURF (nucleosome remodeling factor) complex. |
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| Catalog # | B2853-40A |
| Applications | Suitable for use in Western Blot, Immunohistochemistry and Immunoprecipitation. Other applications not tested. |
| Recommended Dilutions | Immunohistochemistry: 1:100-1:500 |
| Immunohistochemistry (Paraffin): 1:10-1:2000 |
| Western Blot: 1:2000-1:10,000 |
| Immunoprecipitation: 2-5ug/mg lysate |
| Optimal dilutions to be determined by the researcher. |
| Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. |
| Clone Type | Polyclonal |
| Host | Rabbit |
| Source | Human |
| Concentration | ~0.2mg/ml |
| Form | Supplied as a liquid in Tris-buffered Saline, 0.1% BSA, 0.09% sodium azide. |
| Purity | Purified by immunoaffinity chromatography. |
| Immunogen | A synthetic peptide mapping to a region between aa1350-1400 of human Fetal Alzheimer Antigen (Bromodomain and PHD Domain Transcription Factor) (NP_872579.2, GeneID 2186). |
| Specificity | Recognizes human Bromodomain PHD Finger Transcription Factor. |
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| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
| Alternate names | FALZ, Fetal Alzheimer Antigen, Nucleosome Remodeling Factor, Large subunit, Fetal Alz-50 Reactive Clone 1 |
