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Anti -BSEP (Bile Salt Export Pump, SPGP, Sister of P-glycoprotein, ABCB11)
Anti -BSEP (Bile Salt Export Pump, SPGP, Sister of P-glycoprotein, ABCB11)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Affinity Purified |
B IC |
|
| BSEP is involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes. It is expressed predominatly, if not exclusively, in the liver, where it is further localized to the canilicular microvilli and to subcanilicular vesicles fo the hepatocytes. Structurally, BSEP is a multifunctional polypeptide with two homologus halves, each containing a hydrophobic membrane-anchoring domain and an ATP binding cassette (ABC) domain. Defects in BSEP are the cause of progressive familial intrahepatic cholestasis 2 (PFIC2). PFIC2 is an inherited liver disease of childhood which is characterized by cholestasis and normal serum gamma-glutamyltransferase activity. Defects in BSEP are also found in cases of chronic intrahepatic cholestasis without obvious familial history of chronic liver disease. | | | Catalog # | B2916 | | Applications | Suitable for use in Immunocytochemistry and Western Blot. Other applications not tested. | | Recommended Dilutions | Western Blot: 1:50-1:200 | | Immunocytochemistry: Cytospin preparations | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG1 | | Clone No | 6D172 | | Host | Mouse | | Source | Human | | Concentration | ~1mg/ml | | Form | Supplied as a liquid, 0.7% BSA, 100nM sodium azide. | | Purity | Purified by Protein G affinity chromatography. | | Immunogen | Synthetic peptide corresponding to aa705-718, Y705LVHEPPLAVVDHK718 of human BSEP (bile salt export pump). | | Specificity | Recognizes human BSEP. Does not cross-react with human P-glycoprotein. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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