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You are here:Home » Antibodies » Antibodies-CD Markers » Anti -BTLA (B- and T-lymphocyte Attenuator, B- and T-lymphocyte-associated Protein, CD272)

Anti -BTLA (B- and T-lymphocyte Attenuator, B- and T-lymphocyte-associated Protein, CD272)


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Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
B and T lymphocyte attenuator (BTLA) is a 289aa recently identified inhibitory receptor that provides crucial activating or attenuating signals for T cells. It is a third member of co-inhibitory receptors of the CD28 immunoglobulin superfamily with similarities to (CTLA)-4 and (PD)-1 and interacts with a B7 homolog, B7H4. BTLA is constitutively expressed on most CD4+ and CD8+ T cells and its expression progressively decreases upon T cell activation. It remains expressed on Th1 cells but not Th2 cells. BTLA is a unique co-receptor which interacts with the tumor necrosis factor receptor superfamily member Herpes virus entry mediator (HVEM) and this interaction is an important pathway regulating lymphocyte activation and/or homeostasis in the immune response and might also play an important role in the maintenance of T cell tolerance.
Catalog #B5001-61A
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 3-5ug/ml
Optimal dilutions to be determined by the researcher.
Positive ControlHuman spleen lysate
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
FormSupplied as a liquid in PBS, 0.2% gelatin, 0.05% sodium azide.
PurityPurified by Protein G affinity Chromatography.
ImmunogenSynthetic peptide corresponding to aa1-50 of mouse BTLA.
SpecificityRecognizes mouse BTLA. Species sequence homology: chicken, canine, human, rat, xenopus.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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