Login

Forgot your password?
New User?
Remember me
banner banner

You are here:Home » Antibodies » Abs to CD Markers » Anti -BTLA (B- and T-lymphocyte Attenuator, B- and T-lymphocyte-associated Protein, CD272)

Anti -BTLA (B- and T-lymphocyte Attenuator, B- and T-lymphocyte-associated Protein, CD272)

Pricing

  For pricing information, USA customers sign in.
  Outside USA? Please contact your distributor for pricing.

Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
B and T lymphocyte attenuator (BTLA) is a 289aa recently identified inhibitory receptor that provides crucial activating or attenuating signals for T cells. It is a third member of co-inhibitory receptors of the CD28 immunoglobulin superfamily with similarities to (CTLA)-4 and (PD)-1 and interacts with a B7 homolog, B7H4. BTLA is constitutively expressed on most CD4+ and CD8+ T cells and its expression progressively decreases upon T cell activation. It remains expressed on Th1 cells but not Th2 cells. BTLA is a unique co-receptor which interacts with the tumor necrosis factor receptor superfamily member Herpes virus entry mediator (HVEM) and this interaction is an important pathway regulating lymphocyte activation and/or homeostasis in the immune response and might also play an important role in the maintenance of T cell tolerance.
Catalog #B5001-61A
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 3-5ug/ml
Optimal dilutions to be determined by the researcher.
Positive ControlHuman spleen lysate
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceMouse
Concentration~0.5mg/ml
FormSupplied as a liquid in PBS, 0.2% gelatin, 0.05% sodium azide.
PurityPurified by Protein G affinity Chromatography.
ImmunogenSynthetic peptide corresponding to aa1-50 of mouse BTLA.
SpecificityRecognizes mouse BTLA. Species sequence homology: chicken, canine, human, rat, xenopus.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


External Links