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You are here:Home » Antibodies » Abs to Growth Factors, Cytokines » Anti -C-10 (MRP-1, Chemokine C-C motif ligand 6, CCL6)

Anti -C-10 (MRP-1, Chemokine C-C motif ligand 6, CCL6)

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Specifications

Clone Host Grade Applications
Monoclonal Rat Affinity Purified E
Mouse CCL6, a member of the b subfamily of chemokines, was initially identified as a transcript that is induced in bone marrow cells upon stimulation with GM-CSF. A human homologue for mouse CCL6 has not been identified. The mCCL6 cDNA encodes a 116aa precursor protein with a hydrophobic signal peptide that is cleaved to yield a 95aa mature protein. Compared to other chemokines, mCCL6 has a large N-terminal extension. The expression of CCL6 mRNA has been detected in mouse monocytes and neutrophils, where it is strongly induced upon GM-CSF stimulation. CCL6 expression has also been detected in an IL-2-dependent T cell line, where the expression is inhibited following T cell stimulation. Mouse CCL6 expression was also shown to be strongly induced by IL-4 in mouse macrophages. The gene for CCL6 has been mapped to mouse chromosome 11.
Catalog #C0005-09A
ApplicationsSuitable for use in ELISA. Other applications not tested.
Recommended DilutionELISA (capture): 2-8ug/ml using C0005-09B
ELISA (detection): 0.5-2ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG2A
Clone No11n17
HostRat
SourceMouse
Concentration~0.5mg/ml (after reconstitution)
FormSupplied as a lyophilized powder in PBS, pH 7.4, 50ug BSA. Labeled with Biotin. Reconstitute with 200ul sterile PBS.
PurityPurified by Protein A affinity chromatography.
ImmunogenRecombinant protein corresponding to aa22-116 from mouse CCL6/C10 expressed in E. coli (P27784).
SpecificityRecognizes mouse C10. No cross-reactivity or interference with recombinant mouse CCL3, CCL4, or CCL9/10.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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