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Anti -C-10 (MRP-1, Chemokine C-C motif ligand 6, CCL6)
Anti -C-10 (MRP-1, Chemokine C-C motif ligand 6, CCL6)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Rat |
Affinity Purified |
|
|
| Mouse CCL6, a member of the b subfamily of chemokines, was initially identified as a transcript that is induced in bone marrow cells upon stimulation with GM-CSF. A human homologue for mouse CCL6 has not been identified. The mCCL6 cDNA encodes a 116aa precursor protein with a hydrophobic signal peptide that is cleaved to yield a 95aa mature protein. Compared to other chemokines, mCCL6 has a large N-terminal extension. The expression of CCL6 mRNA has been detected in mouse monocytes and neutrophils, where it is strongly induced upon GM-CSF stimulation. CCL6 expression has also been detected in an IL-2-dependent T cell line, where the expression is inhibited following T cell stimulation. Mouse CCL6 expression was also shown to be strongly induced by IL-4 in mouse macrophages. The gene for CCL6 has been mapped to mouse chromosome 11. | | | Catalog # | C0005-09B | | Applications | Suitable for use in ELISA. Other applications not tested. | | Recommended Dilution | ELISA: 0.5-2ug/ml | | ELISA (capture): 2-8ug/ml | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG2A | | Clone No | 11n18 | | Host | Rat | | Source | Mouse | | Concentration | Not determined | | Form | Supplied as a lyophilized powder in PBS, trehalose. Reconstitute with sterile PBS to 0.5mg/ml. | | Purity | Purified by Protein A/G affinity chromatography. | | Immunogen | Recombinant corresponding to aa22-116 from mouse CCL6/C10 expressed in E. coli (P27784). | | Specificity | Recognizes mouse C10. No cross-reactivity or interference with recombinant mouse CCL3, CCL4, or CCL9/10. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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