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You are here:Home » Antibodies » Abs to DNA Replication, Repair » Anti -CCDC88A, CT (Girdin, Akt Phosphorylation Enhancer, APE, Coiled-coil Domain-containing Protein 88A, G alpha-interacting Vesicle-associated Protein, GIV, Girders of Actin Filament, Hook-related Protein 1, HkRP1, APE, GRDN, KIAA1212)

Anti -CCDC88A, CT (Girdin, Akt Phosphorylation Enhancer, APE, Coiled-coil
Domain-containing Protein 88A, G alpha-interacting Vesicle-associated Protein, GIV,
Girders of Actin Filament, Hook-related Protein 1, HkRP1, APE, GRDN, KIAA1212)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B IH
Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. Enhances phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of AKT1/PKB, but does not possess kinase activity itself. Phosphorylation of AKT1/PKB thereby induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation. Essential for the integrity of the actin cytoskeleton and for cell migration. Required for formation of actin stress fibers and lamellipodia. May be involved in membrane sorting in the early endosome.
Catalog #C0005-65
ApplicationsSuitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 1-2ug/ml
Immunohistochemistry (Formalin fixed paraffin embedded): 5ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
HostRabbit
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, 0.02% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to human CCDC88A at C-terminal conjugated to KLH.
SpecificityRecognizes human CCDC88A. Species sequence homology: Mouse, rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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