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You are here:Home » Antibodies » Abs to Complement » Anti -Complement C1q (Complement Component 1, q Subcomponent)

Anti -Complement C1q (Complement Component 1, q Subcomponent)

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Specifications

Clone Host Grade Applications
Polyclonal Goat Affinity Purified E
C1q is serum glycoprotein of 18-polypeptides chains consisting of three non-identical subunits, A (29kD), B (26kD) and C (246aa, 19kD) in molar ratio of 1:2:2. C1Q in the plasma is complexed with two proenzymes C1r and two C1s molecules to form the first component of complement (C1). Activation of complement via classical pathway is triggered by binding of globular head of C1q to immune complexes containing IgG (Fc-region) or IgM or to a variety of other activating substances, including C-reactive protein, retrovirus and mitochondria. Subsequent to C1q binding, c1r and C1s are converted to proteolytic enzymes that are responsible to continuation of activation via the classical pathway. Normal plasma concentration of C1q is 100-180mg/L.
Catalog #C0010-02L
ApplicationsSuitable for use in ELISA. Other applications not tested.
Recommended DilutionsOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostGoat
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, pH 7.2, 0.05% sodium azide.
PurityPurified by immunoaffinity chromatography. 95% by SDS-PAGE.
ImmunogenPurified Human Complement C1q
SpecificityRecognizes human Complement C1q.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesComplement C1q Subcomponent Subunit A, Complement Component 1 q Subcomponent A Chain, C1QA, Complement C1q Subcomponent Subunit B, Complement Component 1 q Subcomponent B Chain, C1QB, Complement C1q Subcomponent Subunit C, Complement Component 1 q Subcomp


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