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You are here:Home » Antibodies » Abs to Complement » Anti -Complement C1q, Human

Anti -Complement C1q, Human

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E B
Acrp30 (adipocyte complement-related protein of 30kD), also known as AdipoQ, APM1, Adiponectin, Gelatin binding protein 28kD/GBP28 or adipocyte most abundant gene transcript) was identified as a novel adipocyte-specific synthesized and secreted protein with structural resemblance to complement factor C1q. Like adipsin, Acrp30 secretion is induced ~10-fold during adipocyte differentiation. Plasma levels are reduced in obese humans, and low levels are associated with insulin-resistance. C1q is serum glycoprotein of 18-polypeptides chains consisting of three nonidentical subunits, A (29kD), B (26kD), and C (246 aa, 19kD)
in molar ratio of 1:2:2. C1Q in the plasma is complexed with two proenzymes C1r and two C1s molecule to form the first component of complement (C1). Activation of complement via classical pathway is triggered by binding of globular head of C1q to immune complexes containing IgG (Fc-region) or IgM or to a variety of other activating substances, including C-reactive protein, retrovirus, and mitochondria. Subsequent to C1q binding, c1r and C1s are converted to proteolytic enzymes that are responsible to continuation of activation via the classical pathway.
Catalog #C0010-07O
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionELISA: 1-2ug/ml.
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG
Clone No9j110
HostMouse
SourceHuman
Concentration~1mg/ml
FormSupplied as a lyophillized powder from PBS, pH 7.4, 0.1% BSA. Reconstitute with 100ul of sterile 40-50% glycerol, PBS.
PurityPurified by Protein A/G affinity chromatography.
ImmunogenComplement C1q, Human
SpecificityRecognizes human Complement C1q.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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