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You are here:Home » Molecular Biology » MB-Complement » Complement C1q, Human

Complement C1q, Human

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Specifications

C1q is serum glycoprotein of 18-polypeptides chains consisting of three non-identical subunits, A (29kD), B (26kD) and C (246aa, 19kD) in molar ratio of 1:2:2. C1Q in the plasma is complexed with two proenzymes C1r and two C1s molecules to form the first component of complement (C1). Activation of complement via classical pathway is triggered by binding of globular head of C1q to immune complexes containing IgG (Fc-region) or IgM or to a variety of other activating substances, including C-reactive protein, retrovirus and mitochondria. Subsequent to C1q binding, c1r and C1s are converted to proteolytic enzymes that are responsible to continuation of activation via the classical pathway. Normal plasma concentration of C1q is 100-180mg/L.
Catalog #C0010-10D
Source
Human Serum/Plasma
Activity
689,000 U/mg
84% C1Q activity in NHS on a mg/ml basis
ApplicationsSuitable for use in ELISA. Other applications not tested
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityAliquot to avoid repeated freezing and thawing and freeze at -70°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquots are stable for at least 6 months.
SourceHuman Plasma
Purity~95% (SDS-PAGE)
Concentration~1mg/ml
FormSupplied as a liquid in 10mM HEPES, pH 7.2, 300mM sodium chloride. No preservative added.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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