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You are here:Home » Antibodies » Abs to Oncoproteins » Anti -Bcr (ALL, BCR1, Breakpoint cluster region protein, CML, D22S11, D22S662, FLJ16453, PHL, Renal carcinoma antigen NY-REN-26)

Anti -Bcr (ALL, BCR1, Breakpoint cluster region protein, CML, D22S11, D22S662, FLJ16453,
PHL, Renal carcinoma antigen NY-REN-26)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Rabbit Supernatant B IP IH IC FC
The breakpoint cluster region protein (Bcr) is best know to be involved in genomic translocation with fusion partner Abl (Cbr-Abl) causing chronic myelogenous leukemia (CML) (1-2). This 160kD protein contains a serine/threonine kinase domain, an SH2 binding domain, a GTP/GDP exchange domain and a C-term domain which functions as a GTPase activating protein for p21rac and CDC42 (3). Additionally, Bcr is involved in signal transduction and can down regulate Ras mediated cell signaling (4).
Catalog #C0013-01B
ApplicationsSuitable for use in Flow Cytometry, Western Blot, Immunoprecipitation, Immunohistochemistry, Immunocytochemistry. Other applications not tested.
Recommended DilutionFlow Cytometry: 1:20
Western Blotting: 1:2,000-10,000
Immunohistochemistry: 1:50-100
Immunocytochemistry: 1:100-250
Immunoprecipitation: 1:60
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Freeze at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Manufactured incorporating RabMAb® technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.
Clone TypeMonoclonal
IsotypeIgG
Clone No6k55
HostRabbit
SourceHuman
FormSupplied as a liquid
PuritySupernatant
ImmunogenA synthetic peptide corresponding to residues in the C-term of human Bcr
SpecificityRecognizes human Bcr
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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