Forgot your password?
New User?
Remember me
banner banner

You are here:Home » Antibodies » Antibodies-Oncoproteins » Anti -Cbl (CBL, CBL2, C-CBL, RNF55, Cas-Br-M (murine) Ecotropic Retroviral Transforming Sequence, Oncogene CBL2)

Anti -Cbl (CBL, CBL2, C-CBL, RNF55, Cas-Br-M (murine) Ecotropic Retroviral Transforming
Sequence, Oncogene CBL2)


  For pricing information, USA customers sign in.
  Outside USA? Please contact your distributor for pricing.


Clone Host Grade Applications
Monoclonal Mouse Affinity Purified B
CBL (Lake Casitas, California mouse B-lineage Lymphoma; also RING finger protein 55) is a 120 -125kD cytosolic member of the CBL family of proteins. It is widely expressed, being found in cells such as fibroblasts, adipocytes, osteoclasts, podocytes and mammary epithelium. CBL negatively regulates RTK signaling by acting as an E3 ubiquitin ligase. Following activation via phosphorylation, CBL will interact with multiple signaling molecules such as Src, ZAP-70, EGFR and SHP1. Human CBL is 906aa in length. It contains an N-terminal phosphoTyr-binding region that consists of one a-helix bundle, an EF hand segment, and an SH2 domain (aa47-342), a RING finger domain that interacts with E2 enzymes (aa381-423) a Pro-rich SH3 domain (aa477-688), and a Leu-zipper/Ubiquitin-associated region (aa86-892). There is one potential alternative start site at Met55. Over (aa775-906, human CBL shares 91% aa identity with mouse CBL.
Catalog #C0013-26K
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 0.5ug/ml
Optimal dilutions to be determined by the researcher.
HybridomaMyeloma cells with B cells from Balb/c mice.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
Clone No11D16
ConcentrationNot determined
FormSupplied as a lyophilized powder in PBS with 5% trelahose. Reconstitute with sterile PBS.
PurityPurified by Protein G affinity chromatography.
ImmunogenRecombinant corresponding to aa775-906 from human CBL expressed in E. coli (P22681).
SpecificityRecognizes human and mouse CBL.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

External Links