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You are here:Home » Antibodies » Abs to Oncoproteins » Anti -Cbl (CBL, CBL2, C-CBL, RNF55, Cas-Br-M (murine) Ecotropic Retroviral Transforming Sequence, Oncogene CBL2)

Anti -Cbl (CBL, CBL2, C-CBL, RNF55, Cas-Br-M (murine) Ecotropic Retroviral Transforming
Sequence, Oncogene CBL2)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
The cbl oncogene was first identified as part of a transforming retrovirus which induces mouse pre-B and pro-B cell lymphomas. As an adaptor protein for receptor protein-tyrosine kinases, it positively regulates receptor protein-tyrosine kinase ubiquitination in a manner dependent upon its variant SH2 and RING finger domains. Ubiquitination of receptor protein-tyrosine kinases terminates signaling by marking active receptors for degradation.
Catalog #C0013-32A
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 0.5-1ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS, 0.02% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to 14aa near the carboxy terminal of human cbl (P22681).
SpecificityRecognizes the carboxy terminus of human Cbl. Species Crossreactivity: mouse and rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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