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You are here:Home » Antibodies » Abs to Transcription Factors, Zinc (Ring) Finger » Anti -CBLB, ID (E3 Ubiquitin-protein Ligase CBL-B, Signal Transduction Protein CBL-B, SH3-binding Protein CBL-B, Casitas B-lineage Lymphoma Proto-oncogene b, RING Finger Protein 56, Nbla00127, RNF56)

Anti -CBLB, ID (E3 Ubiquitin-protein Ligase CBL-B, Signal Transduction Protein CBL-B,
SH3-binding Protein CBL-B, Casitas B-lineage Lymphoma Proto-oncogene b, RING Finger
Protein 56, Nbla00127, RNF56)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B
E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. It also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T-cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. It may also be involved in EGFR ubiquitination and internalization.
Catalog #C0013-32B
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionELISA: 1:1,000
Western Blot: 1:100-1:500
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS, 0.09% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide selected from the Center region of human CBLB (KLH).
SpecificityRecognizes human CBLB.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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