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You are here:Home » Antibodies » Abs to Oncoproteins » Anti -c-erbB2 ( HER2/neu, ErbB2, ErbB-2, Tyrosine Kinase-type Cell Surface Receptor Her2, v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, HER2, HER-2, NEU, NGL, Neuroblastoma- or Glioblastoma-Derived Oncogene Homolog, TKR1)

Anti -c-erbB2 ( HER2/neu, ErbB2, ErbB-2, Tyrosine Kinase-type Cell Surface Receptor Her2,
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, HER2, HER-2, NEU, NGL,
Neuroblastoma- or Glioblastoma-Derived Oncogene Homolog, TKR1)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Rabbit Supernatant B IP IH FC
HER2 / ErbB2 is one of the four members of the ErbB receptor family of transmembrane receptor-like tyrosine kinases (1). The kinase activity of ErbB2 can be activated without ligand if it is overexpressed, and by association with other ErbB proteins (2). Overexpression of ErbB2 is detected in almost 40% of human breast cancers (3). Binding of c-Cbl ubiquitin ligase to Tyr1112 of ErbB2 leads to poly-ubiquitination of ErbB2 and enhances its degradation (4). ErbB2 is one of the major targets for the treatment of breast cancer and other carcinomas.
Applications:
Suitable for use in Flow Cytometry, Western Blot, Immunoprecipitation and Immunohistochemistry. Other applications not tested.
Catalog #C0016-01D
Recommended DilutionsFlow Cytometry: 1:30
Western Blot: 1:50,000-1:100,000
Immunoprecipitation: 1:50
Immunohistochemistry: 1:100-1:250
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 
Manufactured incorporating RabMAb® technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.
Clone TypeMonoclonal
IsotypeIgG
Clone No9E162
HostRabbit
SourceHuman
ConcentrationNot Determined
FormSupplied as a liquid in 50mM Tris-glycine, pH 7.4, 0.15M sodium chloride, 0.05% BSA, 0.01% sodium azide, 40% glycerol.
PuritySupernatant
ImmunogenSynthetic peptide corresponding to residues near the C-terminus of human c-erbB2.
SpecificityRecognizes human c-erbB2 phosphorylated at Tyr1248 as well as unphosphorlyated c-erbB2 at ~185kD.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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