Anti -c-erbB2 ( HER2/neu, ErbB2, ErbB-2, Tyrosine Kinase-type Cell Surface Receptor Her2,
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, HER2, HER-2, NEU, NGL,
Neuroblastoma- or Glioblastoma-Derived Oncogene Homolog, TKR1)
Pricing
For pricing information, USA customers sign in. Outside USA? Please contact your distributor for pricing. Specifications
| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Rabbit |
Supernatant |
B IP IH FC |
|
| HER2 / ErbB2 is one of the four members of the ErbB receptor family of transmembrane receptor-like tyrosine kinases (1). The kinase activity of ErbB2 can be activated without ligand if it is overexpressed, and by association with other ErbB proteins (2). Overexpression of ErbB2 is detected in almost 40% of human breast cancers (3). Binding of c-Cbl ubiquitin ligase to Tyr1112 of ErbB2 leads to poly-ubiquitination of ErbB2 and enhances its degradation (4). ErbB2 is one of the major targets for the treatment of breast cancer and other carcinomas. | | | | | | Applications: | | | Suitable for use in Flow Cytometry, Western Blot, Immunoprecipitation and Immunohistochemistry. Other applications not tested. | | | Catalog # | C0016-01D | | Recommended Dilutions | Flow Cytometry: 1:30 | | Western Blot: 1:50,000-1:100,000 | | Immunoprecipitation: 1:50 | | Immunohistochemistry: 1:100-1:250 | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG | | Clone No | 9E162 | | Host | Rabbit | | Source | Human | | Concentration | Not Determined | | Form | Supplied as a liquid in 50mM Tris-glycine, pH 7.4, 0.15M sodium chloride, 0.05% BSA, 0.01% sodium azide, 40% glycerol. | | Purity | Supernatant | | Immunogen | Synthetic peptide corresponding to residues near the C-terminus of human c-erbB2. | | Specificity | Recognizes human c-erbB2 phosphorylated at Tyr1248 as well as unphosphorlyated c-erbB2 at ~185kD. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
|
|
Questions or comments about this product? Inquire here. |
|
|
Download Specifications for Anti -c-erbB2 ( HER2/neu, ErbB2, ErbB-2, Tyrosine Kinase-type Cell Surface Receptor Her2, v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, HER2, HER-2, NEU, NGL, Neuroblastoma- or Glioblastoma-Derived Oncogene Homolog, TKR1) |
External Links
|
