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You are here:Home » Antibodies » Abs to Enzymes, Phosphatase » Anti -CIP2A (Cancerous Inhibitor of Protein Phosphatase 2A, p90)

Anti -CIP2A (Cancerous Inhibitor of Protein Phosphatase 2A, p90)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E B IC IF
Inhibition of protein phosphatase 2A (PP2A) activity has been identified as a prerequisite for the transformation of human cells. The protein, designated Cancerous Inhibitor of PP2A (CIP2A), interacts directly with the oncogenic transcription factor c-Myc, inhibits PP2A activity toward c-Myc serine 62 (S62), and thereby prevents c-Myc proteolytic degradation. In addition to its function in c-Myc stabilization, CIP2A promotes anchorage-independent cell growth and in vivo tumor formation. The oncogenic activity of CIP2A is demonstrated by transformation of human cells by overexpression of CIP2A. Importantly, CIP2A is overexpressed in two common human malignancies, head and neck squamous cell carcinoma (HNSCC) and colon cancer.
Catalog #C0030-03B3
ApplicationsSuitable for use in ELISA, Western Blot, Immunofluorescence and Immunocytochemistry. Other applications not tested.
Recommended DilutionsWestern Blot: 0.5-2ug/ml. A band is seen at ~90kD
Optimal dilutions to be determined by the researcher.
Recommended ControlH1838: HeLa Nuclear Extract
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG2b,k
Clone No8B68
HostMouse
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in Tris-glycine, 150mM sodium chloride, 0.05% sodium azide.
PurityPurified by Protein G affinity chromatography.
ImmunogenA C-terminal portion of the human p90 protein.
Cellular LocalizationCytoplasmic
SpecificityRecognizes a 300aa portion of human CIP2A (p90 autoantigen).
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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