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You are here:Home » Antibodies » Abs to Cancer Markers » Anti -CA125 Cancer Antigen (Ovarian Cancer) (Glycerol Free & Azide Free) (Biotin)

Anti -CA125 Cancer Antigen (Ovarian Cancer) (Glycerol Free & Azide Free) (Biotin)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E
MUC16/CA125 antigen is a serum marker that is used routinely in gynecologic practice to monitor patients with ovarian cancer. It is a mullerian duct differentiation antigen that is overexpressed in epithelial ovarian cancer cells and secreted into the blood, although its expression is not entirely confined to ovarian cancer. Most biochemical studies have concluded that MUC16/CA125 is a high molecular mass glycoprotein.
Catalog #C0050-01A2
According to the ISOBM-TD-1 workshop, CA125 contains three antigenic domains A-domain (Oc125), B-domain (M11), C-Domain (Ov197). The CA-125 antigen is present on a mucin-like glycoprotein of >200kD and is detectable on the apical surface of normal endometrium and endocervix.
ApplicationsSuitable for use in ELISA. Other applications not tested
Recommended DilutionOptimal dilutions to be determined by the researcher.
SourceAscites fluid
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG1
Clone No2F1
HostMouse
SourceHuman
ConcentrationAs Reported
FormSupplied as a liquid in PBS, pH 7.2. Glycerol and azide-free. Labeled with Biotin.
PurityPurified by Protein A affinity chromatography.
ImmunogenAffinity purified human CA125 antigen.
SpecificityRecognizes B-domain (M11-like) in the protein core of the CA125 ovarian cancer antigen.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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