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You are here:Home » Antibodies » Abs to Cancer Markers » Anti -CA125 Cancer Antigen (Ovarian Cancer)

Anti -CA125 Cancer Antigen (Ovarian Cancer)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E
MUC16/CA125 antigen is a serum marker that is used routinely in gynecologic practice to monitor patients with ovarian cancer. It is a mullerian duct differentiation antigen that is overexpressed in epithelial ovarian cancer cells and secreted into the blood, although its expression is not entirely confined to ovarian cancer. Most biochemical studies have concluded that MUC16/CA125 is a high molecular mass glycoprotein.
Catalog #C0050-01G
According to the ISOBM-TD-1 workshop, CA125 contains three antigenic domains A-domain (Oc125), B-domain (M11), C-Domain (Ov197). The CA-125 antigen is present on a mucin-like glycoprotein of >200kD and is detectable on the apical surface of normal endometrium and endocervix.
ApplicationsSuitable for use in ELISA. Other applications not tested.
Recommended DilutionELISA: concentration 0.5ng/ml can recognize coated 5 IU of CA125/well.
Optimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C. Reconstitute to nominal volume by adding sterile ddH2O, PBS, aliquot and store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG2a
Clone No9A102
HostMouse
SourceHuman
ConcentrationAs reported
FormSupplied as a lyophilized powder from a solution in 0.01M PBS, pH 7.2.
PurityPurified by Protein G affinity chromatography.
ImmunogenHuman CA 125 protein.
SpecificityReacts with human CA125 Cancer Antigen (Ovarian Cancer).
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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