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You are here:Home » Antibodies » Abs to Cancer Markers » Anti -CA125 Cancer Antigen (Ovarian Cancer)

Anti -CA125 Cancer Antigen (Ovarian Cancer)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Supernatant IH
MUC16/CA125 antigen is a serum marker that is used routinely in gynecologic practice to monitor patients with ovarian cancer. It is a mullerian duct differentiation antigen that is overexpressed in epithelial ovarian cancer cells and secreted into the blood, although its expression is not entirely confined to ovarian cancer. Most biochemical studies have concluded that MUC16/CA125 is a high molecular mass glycoprotein.
Catalog #C0050-17
According to the ISOBM-TD-1 workshop, CA125 contains three antigenic domains A-domain (Oc125), B-domain (M11), C-Domain (Ov197). The CA-125 antigen is present on a mucin-like glycoprotein of >200kD and is detectable on the apical surface of normal endometrium and endocervix.
Applications Immunohistochemistry (frozen & formalin/paraffin).
Recommended DilutionImmunohistochemistry: 1:25-1:50. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0 for 10-20 min., followed by cooling at RT for 20 min.
Optimal dilutions to be determined by the researcher.
Clone TypeMonoclonal
IsotypeIgG1
Clone No0.N.37
HostMouse
SourceHuman
ConcentrationNot determined
FormSupplied as concentrated tissue culture supernatant in 15mM sodium azide.
PurityTissue culture supernatant
ImmunogenPartially purified mucin fraction from a pool of cancer tissue from patients with epithelial ovarian cancer.
SpecificityRecognizes CA125 (Ovarian Cancer Antigen). Species Reactivity: Human.
Important NoteThis product is intended for research use only, not for use in human, therapeutic or diagnostic applications.


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