CA15-3, Human (Cancer Antigen 15-3) BioAssay™ ELISA Kit
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| Breast cancer is the most common life-threatening malignant lesion in women of many developed countries today, with approximately 180,000 new cases diagnosed every year. Roughly half of these newly diagnosed patients are node-negative, however 30% of these cases progress to metastatic disease. There are a number of tumor markers that can help clinicians to identify and diagnose which breast cancer patients will have aggressive disease and which will have an indolent course. These markers include estrogen and progesterone receptors, DNA ploidy and percent-S phase profile, epidermal growth factor receptor, HER-2/neu oncogene, p53 tumor suppressor gene, cathepsin D, proliferation markers and CA15-3. CA15-3 is most useful for monitoring patients post-operatively for recurrence, particularly metastatic diseases. 96% of patients with local and systemic recurrence have elevated CA15-3, which can be used to predict recurrence earlier than radiological and clinical criteria. A 25% increase in the serum CA15-3 is associated with progression of carcinoma. A 50% decrease in serum CA15-3 is associated with response to treatment. CA15-3 is more sensitive than CEA in early detection of breast cancer recurrence. In combination with CA125, CA15-3 has been shown to be useful in early detection of relapse of ovarian cancer. CA15-3 levels are also increased in colon, lung and hepatic tumors. | | | Catalog # | C0050-24H | | Sample Type | Serum | | Intended Use | For the quantitative determination of the Cancer Antigen CA15-3 concentration in human serum. | | Kit Components | Microtiter plate with 1x96 wells. | | Murine Monoclonal Anti-CA15-3 coated | | Sample Diluent, 1x100ml | | Enzyme Conjugate Concentrate (22X), 1x1ml | | Enzyme Conjugate Diluent, 1x21ml | | Standard , 0unit/ml, 1x1vial Standard, 15unit/ml, 1x1vial Standard, 30unit/ml, 1x1vial Standard, 60unit/ml, 1x1vial Standard, 120unit/ml, 1x1vial Standard, 240Unit/ml, 1x1vial. Wash Buffer Concentrate (20X), 1x50ml TMB Reagent (One-Step), 1x11ml Stop Solution (1N HCl), 1x11ml | | Storage and Stability | Store all components at 4°C. Stable for at least 6 months. For maximum recovery of product, centrifuge the original vial prior to removing the cap. | |
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