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You are here:Home » Molecular Biology » MB-Cancer Markers » Cachectic Factor Control, Human, Control Peptide (CF)

Cachectic Factor Control, Human, Control Peptide (CF)

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Specifications

Control Peptide for (affinity purified) and (antiserum).
18-aa peptide of human CF
Catalog #C0104-49D
Cancer cachexia is a syndrome of progressive wasting which is believed to be mediated by tumor necrosis factor-alpha, interleukins 1 and 6, and interferon-gamma, and leukemia-inhibitory factor. However, the levels of these putative agents do not correlate with cachexia. Recently, a new circulating tumor factor, termed cachectic factor (CF), has been isolated and characterized from the urine of mice transplanted with adenocarcinoma MAC16 (1). Purified CF, a proteoglycan of relative mol. Wt of ~24kD, produces cachexia in vivo by inducing catabolism of skeletal muscle. CF was also found in urine of cachectic cancer patients. It is not found in normal urine, patient with weight loss due to trauma, and cancer patient with no weight loss (1).
CF appears to be ~24 K on SDS-gels. It is a sulfated glycoprotein. The amino acid analyses was determined as YSP EAA SAP GSG DPS HEA. An antibody raised to the CF also recognized a 69kD band with the same amino acid sequence as the 24 K material.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
PurityPurified.
ConcentrationAs reported
FormSupplied as a lyophilized powder from PBS, 0.05% sodium azide.
SpecificityThe 18 AA human CF is unique to CF. It has some sequence homology with streptococcal preadsorbing antigen involved in pathogenesis of acute post-streptococcal glomerulonephritis (2). No significant sequence homology is detected with other proteins.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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