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Anti -CACNB4 (Calcium channel, voltage-dependent, beta 4 subunit; CAB4; CACNLB4; EA5; EJM; dihydropyridine-sensitive L-type; calcium channel beta-4 subunit; voltage dependent calcium channel beta 4 subunit)
Anti -CACNB4 (Calcium channel, voltage-dependent, beta 4 subunit; CAB4; CACNLB4; EA5; EJM;
dihydropyridine-sensitive L-type; calcium channel beta-4 subunit; voltage dependent
calcium channel beta 4 subunit)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Goat |
Affinity Purified |
E B |
|
| This gene encodes a member of the beta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. The protein described in this record plays an important role in calcium channel function by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Certain mutations in this gene have been associated with idiopathic generalized epilepsy (IGE) and juvenile myoclonic epilepsy (JME). Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized. | | | Catalog # | C0104-80R | | Positive Control | Human Bone Marrow lysate | | Applications | Suitable for use in ELISA and Western Blot. Other applications not tested. | | Recommended Dilution | ELISA: 1:4000. | | Western Blot: 0.2-0.6ug/ml. ~ 55-60kD band observed in Human Bone Marrow lysates (calculated MW of 54.7kD according to NP_001005747.1 and 58.2kD according to NP_000717.2). | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | | | May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Goat | | Source | Human | | Concentration | ~0.5mg/ml | | Form | Supplied as a liquid in Tris-saline, pH7.2, 0.5% BSA. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Synthetic peptide, C-DYPDSYQDTYKPH, representing the internal region (near the C Terminus) of the human protein according to NP_001005747.1; NP_000717.2; NP_001005746.1. Homology | | Specificity | Species Crossreactivity: Human. Other species not tested. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. | | Alternate names | Calcium channel, voltage-dependent, beta 4 subunit; CAB4; CACNLB4; EA5; EJM; dihydropyridine-sensitive L-type; calcium channel beta-4 subunit; voltage dependent calcium channel beta 4 subunit |
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