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You are here:Home » Antibodies » Abs to Cadherin » Anti -Cadherin N (CDH2, Cadherin 2, type 1, N-cadherin (neuronal), Cadherin-2, Cadherin-2 precursor, CD325, CD325 antigen, CDHN, CDw325, CDw325 antigen, NCAD, N-cadherin, Neural-cadherin, Neural-cadherin precursor)

Anti -Cadherin N (CDH2, Cadherin 2, type 1, N-cadherin (neuronal), Cadherin-2, Cadherin-2
precursor, CD325, CD325 antigen, CDHN, CDw325, CDw325 antigen, NCAD, N-cadherin,
Neural-cadherin, Neural-cadherin precursor)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Purified IH
Cadherins are transmembrane glycoproteins involved in Ca++ dependent cell adhesion (1). The cadherin family, including (E)pithelial-Cadherin, (N)euronal-Cadherin, (P)lacental-Cadherin and (R)etinal-Cadherin, plays an important role in tissue morphogenesis and structure. N-cadherin (136kD) is expressed in nerve cells, developing skeletal muscle, embryonic and mature cardiac muscle cells, and pleural mesothelial cells.
Studies have indicated that analysis of E-cadherin and N-cadherin expression may be useful in differentiating pleural mesotheliomas (N-cadherin positive) and lung adenocarcinomas (E-cadherin positive) (2).
Catalog #C0107-03
ApplicationsSuitable for use in Immunohistochemistry. Other applications not tested. Other applications not tested.
Recommended DilutionImmunohistochemistry: Formalin-fixed, paraffin-embedded sections. 1:50-1:100 Citrate buffer, pH6.0 retrieval required
Optimal dilutions to be determined by the researcher.
Recommended Positive ControlBrain, pancreas
Expected Staining PatternMembrane
Epitope RetrievalRequired (Citrate buffer, pH6.0).
Enzyme DigestionNot required
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG1,k
Clone No3G40
HostMouse
Concentration~1mg/ml
FormSupplied as a liquid in PBS, pH 7.4, 1% BSA, 0.1% sodium azide.
PurityPurified.
ImmunogenRecombinant protein corresponding to an intracellular domain of chicken N-cadherin.
SpecificityRecognizes human N-cadherin. Does not crossreact with other cadherin family members including P- and E-cadherins.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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