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Abs to Cadherin
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Anti -Cadherin N (Cadherin-2, CDw325, Neural Cadherin, N-cadherin, CD325, CDH2, CDHN, NCAD)
Anti -Cadherin N (Cadherin-2, CDw325, Neural Cadherin, N-cadherin, CD325, CDH2, CDHN,
NCAD)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Ascites |
IH |
|
| Cadherins are a family of transmembrane glycoproteins responsible for maintaining the integrity of tissue and are involved in cell differentiation, cell migration and intracellular adhesion through a calcium dependent mechanism characterized by homotypic adhesion.Their highly conserved cytoplasmic domains associated with catenins, thus mediating contact between cadherins and the microfilaments of cytoskeleton. Each cadherin subclass, shows a unique tissue distribution with E-cadherin expressed in epithelial cells and P-cadherin restricted to decidua tissue and the basal or lower layers of stratified epithelium. Cadherins are expressed in a tissue specific manner and and are required for assembly of cells into solid tissue. Cadherins play an important part in tumor invasion and metastasis. | | | Catalog # | C0107-03H | | Applications | Suitable for use in Immunohistochemistry. Other applications not tested. | | Recommended Dilution | Immunohistochemistry (formalin fixed paraffin embedded): 1:25-1:50 (ABC) | | Optimal dilutions to be determined by the researcher. | | Positive Control | Tonsil | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG1 | | Clone No | 11E38 | | Host | Mouse | | Source | Chicken | | Concentration | Not determined. | | Form | Supplied as a liquid, sodium azide. | | Purity | Ascites | | Immunogen | Synthetic peptide corresponding to the C-terminal of chicken N-Cadherin with extra N-terminal lysine residue. Cellular Localization: Cell membrane | | Specificity | Recognizes chicken Cadherin, pan. Species Crossreactivity: bovine, feline, canine, goat, guinea pig, hamster. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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