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You are here:Home » Antibodies » Abs to Cadherin » Anti -Cadherin 11 (OB-Cadherin, Osteoblast, CDH11)

Anti -Cadherin 11 (OB-Cadherin, Osteoblast, CDH11)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Supernatant IH
The cadherin gene family encodes calcium-dependent adhesion molecules that promote homophilic interactions among cells. All cadherins are single-pass transmembrane proteins with a variable number of extracellular ecommended for PC-3 cell line (human prostate cell line)domains (EC; 110 amino acids long). Classical cadherins consist of five EC domains and a conserved cytoplasmic domain and are divided in type I and type II subgroups. Type I comprises cadherin E, N, P, and R. Type II include cadherin- 5, -6, -8, -11, and -12. Cadherin-11 (OB-cadherin) is a marker of the loosely connected and migratory cellular elements of the mesenchyme. Strong expression of cadherin-11 has been found in brain, spinal cord, bone marrow and bone cells, and it is regulated in human endometrial glandular epithelial and stromal cells. Recently, cadherin-11 mRNA and protein were found to be expressed in most invasive breast cancer cell lines tested (but not in non-invasive cell lines), suggesting cadherin-11 as a potential marker for aggressive, invasive tumor subsets.
Catalog #C0107-06A
ApplicationsSuitable for use in Immunohistochemistry (frozen sections, paraformaldehyde fixed; with 0.2% Triton X-100 in PBS)
Other applications have not been tested.
Recommended DilutionImmunohistochemistry: Incubation Time 1 hr at RT / overnight at 4°C. Dilute immediately before use in PBS.
Optimal dilutions to be determined by the researcher.
Recommended Positive controlPC-3 cell line (human prostate cell line)
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG1
Clone No5F82
HostMouse
ConcentrationNot determined
FormSupplied as a liquid in 0.1% sodium azide.
PurityCulture supernatant
ImmunogenGST fusion protein of part of the extracellular domain of human cadherin 11 (OB-Cadherin).
SpecificityRecognizes human Cadherin 11.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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