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Anti -Cadherin 11 (OB-Cadherin, Osteoblast, CDH11)
Anti -Cadherin 11 (OB-Cadherin, Osteoblast, CDH11)
Pricing
For pricing information, USA customers sign in. Outside USA? Please contact your distributor for pricing. Specifications
| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Supernatant |
IH |
|
| The cadherin gene family encodes calcium-dependent adhesion molecules that promote homophilic interactions among cells. All cadherins are single-pass transmembrane proteins with a variable number of extracellular ecommended for PC-3 cell line (human prostate cell line)domains (EC; 110 amino acids long). Classical cadherins consist of five EC domains and a conserved cytoplasmic domain and are divided in type I and type II subgroups. Type I comprises cadherin E, N, P, and R. Type II include cadherin- 5, -6, -8, -11, and -12. Cadherin-11 (OB-cadherin) is a marker of the loosely connected and migratory cellular elements of the mesenchyme. Strong expression of cadherin-11 has been found in brain, spinal cord, bone marrow and bone cells, and it is regulated in human endometrial glandular epithelial and stromal cells. Recently, cadherin-11 mRNA and protein were found to be expressed in most invasive breast cancer cell lines tested (but not in non-invasive cell lines), suggesting cadherin-11 as a potential marker for aggressive, invasive tumor subsets. | | | Catalog # | C0107-06A | | Applications | Suitable for use in Immunohistochemistry (frozen sections, paraformaldehyde fixed; with 0.2% Triton X-100 in PBS) | | Other applications have not been tested. | | Recommended Dilution | Immunohistochemistry: Incubation Time 1 hr at RT / overnight at 4°C. Dilute immediately before use in PBS. | | Optimal dilutions to be determined by the researcher. | | Recommended Positive control | PC-3 cell line (human prostate cell line) | | Storage and Stability | May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG1 | | Clone No | 5F82 | | Host | Mouse | | Concentration | Not determined | | Form | Supplied as a liquid in 0.1% sodium azide. | | Purity | Culture supernatant | | Immunogen | GST fusion protein of part of the extracellular domain of human cadherin 11 (OB-Cadherin). | | Specificity | Recognizes human Cadherin 11. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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