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You are here:Home » Antibodies » Abs to Cadherin » Anti -Cadherin 11 (OB-Cadherin, Osteoblast, CDH11)

Anti -Cadherin 11 (OB-Cadherin, Osteoblast, CDH11)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B
Cadherin-11, a mesenchymal adherin,2 is localized to the cell membrane in a detergent-soluble complex, where it associates with a-and b-catenin , and may facilitate tumor cell invasion and metastasis.4 Cadherin-11 exists as two alternatively spliced forms, cadherin-11 (OB cadherin) and cadherin-11 variant (OB-cadherin-2). The variant form is a truncated protein with an unusual cytoplasmic domain, that is not present in other cadherins.3 Both wildtype and variant form of cadherin-11 are expressed in invasive and poorly differentiated breast cancer cell lines.4 A study has shown that the presence of cadherin-11 splice variant promotes the invasion of cadherin-11 positive breast cancer cells.1
Catalog #C0107-09
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionELISA: 0.1-1ug/ml
Western Blot: 1-3ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilitystorglyMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration0.25 mg/ml
FormSupplied as a liquid in PBS, 0.1% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide derived from the C-terminal region of the human Cadherin-11 Variant (OB-cadherin-2) protein.
SpecificityRecognizes the C terminal region of human Cadherin-11 Variant protein. On Western blots, it identi es a single band at ~85kD. Western blots using wildtype cadherin-11 transfected HEK293 cells yielded negative results. Reactivity has been con rmed with Cadherin-11 Variant transfected human HEK293 cell lysates.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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