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Anti -Cadherin 11 (OB-Cadherin, Osteoblast, CDH11)
Anti -Cadherin 11 (OB-Cadherin, Osteoblast, CDH11)
Pricing
For pricing information, USA customers sign in. Outside USA? Please contact your distributor for pricing. Specifications
| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
E B |
|
| Cadherin-11, a mesenchymal adherin,2 is localized to the cell membrane in a detergent-soluble complex, where it associates with a-and b-catenin , and may facilitate tumor cell invasion and metastasis.4 Cadherin-11 exists as two alternatively spliced forms, cadherin-11 (OB cadherin) and cadherin-11 variant (OB-cadherin-2). The variant form is a truncated protein with an unusual cytoplasmic domain, that is not present in other cadherins.3 Both wildtype and variant form of cadherin-11 are expressed in invasive and poorly differentiated breast cancer cell lines.4 A study has shown that the presence of cadherin-11 splice variant promotes the invasion of cadherin-11 positive breast cancer cells.1 | | | Catalog # | C0107-09 | | Applications | Suitable for use in ELISA and Western Blot. Other applications not tested. | | Recommended Dilution | ELISA: 0.1-1ug/ml | | Western Blot: 1-3ug/ml | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | storglyMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | 0.25 mg/ml | | Form | Supplied as a liquid in PBS, 0.1% sodium azide. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Synthetic peptide derived from the C-terminal region of the human Cadherin-11 Variant (OB-cadherin-2) protein. | | Specificity | Recognizes the C terminal region of human Cadherin-11 Variant protein. On Western blots, it identi es a single band at ~85kD. Western blots using wildtype cadherin-11 transfected HEK293 cells yielded negative results. Reactivity has been con rmed with Cadherin-11 Variant transfected human HEK293 cell lysates. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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