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Anti -Cadherin E (Cadherin 1, E-Cadherin, L-CAM, Epithelial Cell Adhesion Molecule, Uvomorulin, CDH1)
Anti -Cadherin E (Cadherin 1, E-Cadherin, L-CAM, Epithelial Cell Adhesion Molecule,
Uvomorulin, CDH1)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Supernatant |
IH |
|
| E-cadherin (uvomorulin, cell- CAM120/80) is a calcium dependent cell adhesion molecule expressed predominately in epithelial tissues. It plays an important role in the growth and development of cells via the mechanisms of control of tissue architecture and the maintenance of tissue integrity. Numerous studies have demonstrated that reduction and/or loss of E-cadherin expression in carcinomas correlates positively with the potential of these tumors for invasion and metastasis. May prove useful in studies of primary tumors and metastatic lesions. | | | Catalog # | C0108-25K | | Applications | Suitable for use in Immunohistochemistry. | | Other applications not tested. | | Recommended Dilution | Immunohistology (Formalin/paraffin only): (Use Ab at 1:20 to 1:40 for 90 min at RT) Staining of formalin-fixed tissues REQUIRES boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 min. | | Positive Control | Tonsil, squamous epithelium | | Epitope | N-terminal. | | Cellular Localization | Cell membrane | | Storage and Stability | May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Store at -20°C or colder. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG1 | | Clone No | 5G22 | | Host | Mouse | | Source | Human | | Concentration | Not determined | | Form | Supplied as a liquid with 0.09% sodium azide. | | Purity | Culture supernatant | | Immunogen | Recombinant protein encoding the N-terminal region of E-cadherin molecule. | | Specificity | Recognizes E-cadherin. Species Crossreactivity: Human. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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