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You are here:Home » Antibodies » Abs to Cadherin » Anti -Cadherin E (Epithelial Cadherin, E-Cadherin, ECAD, CDHE, Arc 1, Arc-1, Cadherin 1, Cadherin-1, CDH1, CAM 120/80, CAM-120/80, CD324, CD324 Antigen, LCAM, Uvomorulin, UVO)

Anti -Cadherin E (Epithelial Cadherin, E-Cadherin, ECAD, CDHE, Arc 1, Arc-1, Cadherin 1,
Cadherin-1, CDH1, CAM 120/80, CAM-120/80, CD324, CD324 Antigen, LCAM, Uvomorulin, UVO)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Purified B IH IC
One of the epithelial cell adhesion molecules, E-Cadherin, plays an important role in the formation of cell-cell contacts in epithelia irrespective their origin form ecto-, meso- or endodermal tissue. This early adhesion event between epithelial cells is a prerequisite for the assembly of all elements of the junctional complex. Furthermore, E-Cadherin plays a crucial role in the maintenance of the epithelial junctional complex and is as such an important molecule in maintaining epithelial integrity. Over 90% of the malignant tumors are carcimomas. One of the prerequisites for the release of carcinoma cells from the primary site might be a defect in intercellular adhesion mediated by the absence of E-Cadherin expression. Therefore, the expression of E-Cadherin might be an important parameter for the determination of the invasive potential of epithelial neoplasms, and for the transition of a benign to a malignant neoplasm.
Catalog #C0108-25W
ApplicationsSuitable for use in Western Blot, Immunohistochemistry and Immunocytochemistry. Other applications not tested.
Recommended DilutionImmunohistochemistry (Frozen): 1:10-1:40 using the indirect method. Dilute immediately before use with PBS or Tris. Fix frozen sections with acetone or formaldehyde.
Immunocytochemistry: 1:10-1:40 using the indirect method. Stains cell suspensions. Dilute immediately before use with PBS or Tris.
Optimal dilutions to be determined by the researcher.
Positive ControlCell line MCF-7, human small Intestine.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 
Clone TypeMonoclonal
IsotypeIgG1
Clone No6F9
HostMouse
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid.
PurityPurified
ImmunogenE-Cadherin isolated from human placenta. Cellular Localization: Extracellular, basement membranes
SpecificityRecognizes human E-cadherin. Reacts specifically with the 120 and 80kD ARC-1 protein.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesCadherin 1 Type 1 E-cadherin (Epithelial)


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