Anti -Cadherin E (Epithelial Cadherin, E-Cadherin, ECAD, CDHE, Arc 1, Arc-1, Cadherin 1,
Cadherin-1, CDH1, CAM 120/80, CAM-120/80, CD324, CD324 Antigen, LCAM, Uvomorulin, UVO)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Purified |
B IH IC |
|
| One of the epithelial cell adhesion molecules, E-Cadherin, plays an important role in the formation of cell-cell contacts in epithelia irrespective their origin form ecto-, meso- or endodermal tissue. This early adhesion event between epithelial cells is a prerequisite for the assembly of all elements of the junctional complex. Furthermore, E-Cadherin plays a crucial role in the maintenance of the epithelial junctional complex and is as such an important molecule in maintaining epithelial integrity. Over 90% of the malignant tumors are carcimomas. One of the prerequisites for the release of carcinoma cells from the primary site might be a defect in intercellular adhesion mediated by the absence of E-Cadherin expression. Therefore, the expression of E-Cadherin might be an important parameter for the determination of the invasive potential of epithelial neoplasms, and for the transition of a benign to a malignant neoplasm. | | | Catalog # | C0108-25W | | Applications | Suitable for use in Western Blot, Immunohistochemistry and Immunocytochemistry. Other applications not tested. | | Recommended Dilution | Immunohistochemistry (Frozen): 1:10-1:40 using the indirect method. Dilute immediately before use with PBS or Tris. Fix frozen sections with acetone or formaldehyde. | | Immunocytochemistry: 1:10-1:40 using the indirect method. Stains cell suspensions. Dilute immediately before use with PBS or Tris. | | Optimal dilutions to be determined by the researcher. | | Positive Control | Cell line MCF-7, human small Intestine. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG1 | | Clone No | 6F9 | | Host | Mouse | | Source | Human | | Concentration | As reported | | Form | Supplied as a liquid. | | Purity | Purified | | Immunogen | E-Cadherin isolated from human placenta. Cellular Localization: Extracellular, basement membranes | | Specificity | Recognizes human E-cadherin. Reacts specifically with the 120 and 80kD ARC-1 protein. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. | | Alternate names | Cadherin 1 Type 1 E-cadherin (Epithelial) |
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Download Specifications for Anti -Cadherin E (Epithelial Cadherin, E-Cadherin, ECAD, CDHE, Arc 1, Arc-1, Cadherin 1, Cadherin-1, CDH1, CAM 120/80, CAM-120/80, CD324, CD324 Antigen, LCAM, Uvomorulin, UVO) |
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