Anti -Cadherin E (Cadherin-1, CAM 120/80, Epithelial Cadherin, E-cadherin, Uvomorulin,
CD324, CDH1, CDHE, UVO)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Purified |
B IH FC N |
|
| E-Cadherin, also known as L-CAM (Liver Cell Adhesion Molecule), and CD324, is an epithelial cell adhesion molecule which plays an important role in the formation of cell-cell contacts in epithelia. This early adhesion event between epithelial cells is a prerequisite for the assembly of all elements of the junctional complex and as such is important in maintaining epithelial integrity. E-Cadherin may also play a key role in tumor suppression. Over 90% of malignancies are carcinomas, and one of the prerequisites for the release of carcinoma cells from the primary site appears to be a defect in intercellular adhesion mediated by the absence of E-cadherin expression. Thus, expression of E-cadherin could be an important parameter for determination of the invasive potential of epithelial neoplasms, and for the transition of neoplasm from benign to malignancy. | | | Catalog # | C0108-25Y | | Applications | Suitable for use in Flow Cytometry, Western Blot, Neutralization and Immunohistochemistry. Other applications not tested. | | Recommended Dilutions | Western Blot: 1:100 | | Immunohistochemistry: Frozen sections | | Optimal dilutions to be determined by the researcher. | | Positive Control | Human lung cell line | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG1 | | Clone No | 11E39 | | Host | Mouse | | Source | Human | | Concentration | Not Determined | | Form | Supplied as a liquid, 0.05% sodium azide. | | Purity | Purified | | Immunogen | Human breast carcinoma cell line T471. Cellular Localization: Cell membrane. | | Specificity | Recognizes human Cadherin E. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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