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You are here:Home » Antibodies » Antibodies-Cadherin » Anti -Cadherin E (Cadherin 1, E-Cadherin, L-CAM, Epithelial Cell Adhesion Molecule, Uvomorulin, CDH1)

Anti -Cadherin E (Cadherin 1, E-Cadherin, L-CAM, Epithelial Cell Adhesion Molecule,
Uvomorulin, CDH1)


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Clone Host Grade Applications
Monoclonal Mouse Purified IH
Cadherins are transmembrane glycoproteins involved in Ca++-dependent cell adhesion. The cadherin family, including E-Cadherin, N-Cadherin, P-Cadherin and R-Cadherin, plays an important role in tissue morphogenesis and structure. E- cadherin is a 120kD protein that mediates Ca++-dependent adhesion between epithelial cells and is involved in the generation of epithelial layers during development and the and maintenance of epithelial tissue in adults. The presence of E-cadherin has been reported in other cell types, including osteoblasts, peripheral nerve Schwann cells and Langerhans cells. The large number of papers linking E-cadherin, or lack of E-cadherin expression, with a broad range of cancers suggests that its immunodetection in tissue may be useful in the diagnosis and prognosis of a variety of cancers. Tumor analysis by immunohistochemical techniques revealed that the reduction and/or loss of E-cadherin expression in carcinomas (including tumors of the neck, prostate, esophagus and other cancers) correlates positively with tumor cell invasion and metastasis. Studies have also associated reduced expression of E-cadherin with invasiveness and poor prognosis in breast cancer and poor prognosis in bladder cancer. Other studies have indicated that analysis of E-cadherin and N-cadherin expression may be useful in differentiating pleural mesotheliomas (N-cadherin positive) and lung adenocarcinomas (E-cadherin positive).
Suitable for use in Immunohistochemistry. Other applications not tested.
Catalog #C0108-34E
Recommended DilutionsImmunohistochemistry (Formalin-fixed, paraffin-embedded or frozen sections): 1:50-1:200. Epitope retrieval required (Citrate Buffer, pH 6).
Optimal dilutions to be determined by the researcher.
Recommended Positive ControlNon-neural epithelia tissue
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
Clone No3G47
FormSupplied as a liquid in PBS, pH 7.4, 1% BSA, 0.1% sodium azide.
ImmunogenRecombinant protein corresponding to the cytoplasmic domain of human E-Cadherin.
SpecificityRecognizes human Cahedrin E. Expected Staining Pattern: Mainly cellular membrane, some cytoplasmic.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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