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You are here:Home » Antibodies » Abs to Cadherin » Anti -CDH2 (N-Cadherin, Cadherin-2, CDw325, Neural Cadherin, N-cadherin, CD325, CDHN, NCAD) (APC)

Anti -CDH2 (N-Cadherin, Cadherin-2, CDw325, Neural Cadherin, N-cadherin, CD325, CDHN,
NCAD) (APC)

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Specifications

Clone Host Grade Applications
Polyclonal Sheep Affinity Purified FC
N-Cadherin (Neural Cadherin; also known as CD325 and Cadherin-2) is a 130-135kD member of the "classical" (or type I) cadherin subfamily, cadherin superfamily of proteins. It is expressed on multiple cell types, including neurons, fibroblasts, Schwann cells, endothelial cells, and hepatic stellate cells. N-Cadherin mediates homotypic binding, either in cis or trans (adjacent cell). Pro-N-Cadherin is expressed as an 881aa type I transmembrane glycoprotein. It may be initially inserted into the endoplasmic reticulum, where the 15-20kD prodomain (aa26-159) is cleaved by Proprotein Convertase, and the mature molecule (aa160-906) is transported to the surface. Mature N-Cadherin contains a 565aa extracellular region (aa160-724) that possesses five cadherin domains (aa160-714), and a 161aa cytoplasmic tail that undergoes phosphorylation at 785aa. There is one splice variant that contains a 10aa substitution for aa839-906. Over aa160-724, human N-Cadherin shares 98% aa identity with mouse N-Cadherin.
Catalog #C0108-35B
ApplicationsSuitable for use in Flow Cytometry. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Absorption 620-650nm
Emission 660-670nm
Storage and StabilityMay be stored at 4°C before opening. DO NOT FREEZE! Stable at 4°C as an undiluted liquid. Dilute only prior to immediate use. Stable for 12 months. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer. APC is light sensitive.
Clone TypePolyclonal
IsotypeIgG
HostSheep
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid in saline, 0.5% BSA, 0.1% sodium azide. Labeled with Allophycocyanin (APC).
PurityPurified by immunoaffinity chromatography.
ImmunogenRecombinant corresponding to aa160-724 from human N-Cadherin extracellular domain expressed in NSO cell line.
SpecificityRecognizes human N-Cadherin.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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