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Specifications

Clone Host Grade Applications Monoclonal Rat Highly Purified B IP IH

The cadherin superfamily of proteins are a group of calcium mediated cell-cell adhesion molecules. Cadherins are responsible for a whole range of processes including development, wound healing, cell-cell signaling, cell growth and differentiation. N-cadherin is found in many locations including cardiac adherins junctions, oral squamous epithelial cells, and breast epithelial cells. Studies have linked N-cadherin to cancer metastasis by showing the aggressive tumor cells had preferentially turned on N-cadherin as opposed to E- or P-cadherin.
Catalog #	C0108-35G
Applications	Suitable for use in Immunohistochemistry, Western Blot, Inhibition, Immunoprecipitation, Affinity Chromatography, Epitope Mapping and Adhesion Inhibition. Other applications not tested.
Recommended Dilution	Immunohistochemistry: 10ug/ml
	Western Blot: 1-10ug/ml
	Inhibition of N-cadherin-dependent cell-cell contact: 100ug/ml for adhesion blocking
	Optimal dilutions to be determined by the researcher.
Hybridoma	P3X63-Ag8.U1 myeloma cells with spleen cells from Balb/c mice.
Storage and Stability	Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
CAS Number	n/a
Clone Type	Monoclonal
Isotype	IgG2a
Clone No	3G48
Host	Rat
Source	Chicken
Concentration	~2mg/ml
Form	Supplied as a lyophilized powder from PBS, 1% BSA. No preservatives added. Reconstitute with 50ul sterile ddH2O. Dilute further with PBS, 1% BSA, 0.1% sodium azide.
Purity	Puri ed by ammonium sulfate precipitation and anion exchange chromatography.
Immunogen	Neuronal tissue of chick embryos
Specificity	Recognizse chicken N-cadherin. Species Crossreactivity: Xenopus
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.