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You are here:Home » Antibodies » Abs to Cadherin » Anti -Cadherin P (Cadherin 3, Placental, CDH3)

Anti -Cadherin P (Cadherin 3, Placental, CDH3)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Supernatant IH
Cadherins are a family of CA2+ dependent intercellular adhesion molecules that play a central role in controlling morphogenetic movements during development. Their function is regulated by association with the actin cytoskeleton by a complex of cytoplasmic proteins called the catenin (alpha, beta and gamma). Members of the cadherin family include Cadherin 6 (K-Cadherin), P-cadherin (MW 120kD), E-cadherin (uvomorulin), N-cadherin (neural cadherin), R-Cadherin, cadherin 5, L-CAM and EP-Cadherin.
P-cadherin is an 882 amino acid polypeptide with a putative signal peptide, a putative precursor region, an extracellular domain containing internal repeats, and a highly hydrophobic transmembrane region. Amino acid sequences among P-, E- and N-cadherin are most conserved in the cytoplasmic domain followed by conservation of the N-terminal region of the extracellular domain. The cytoplasmic domain provides a link to the cytoskeleton through the associated catenin proteins. The mouse P-cadherin genes have been shown to be tightly linked on chromosome 8. The human E-cadherin gene has been localized to chromosome 16p11-16qter. Changes in P-cadherin expression have been implicated in breast and melanocytic tumors.
Catalog #C0108-37A
ApplicationsSuitable for use in Immunohistochemistry. Other applications not tested.
Recommended DilutionImmunohistochemistry (Formalin/paraffin): 1:20 for 30 min at RT. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 min.
Optimal dilutions to be determined by the researcher.
Positive Control Skin
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG1
Clone No3D5
HostMouse
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid, 0.09% sodium azide.
PuritySupernatant
ImmunogenRecombinant protein corresponding to extracellular domain of human P-cadherin. Cellular Localization
SpecificityRecognizes human P-Cadherin (120kD).
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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