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Anti -Cadherin R (Cadherin 4, Cadherin-4, Retinal Cadherin, CDH4, R-CAD, R-cadherin)
Anti -Cadherin R (Cadherin 4, Cadherin-4, Retinal Cadherin, CDH4, R-CAD, R-cadherin)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Sheep |
Affinity Purified |
B IH |
|
| Cadherin-4 (also Retinal/R-Cadherin) is a 120kD (100kD predicted) member of the classical cadherin family of molecules. It is expressed on mammary epithelium, olfactory bulb neurons, cerebellar granule cells, vascular smooth muscle, astrocytes and pancreatic B-cells. Cadherin-4 forms both homodimers and heterodimers with N-cadherin. These complexes will oligomerize, providing sources for adhesion and migration. Cadherin-4 also binds to KLRG1 expressed on NK, T and Treg lymphocytes. Mouse cadherin-4 proprecursor is 893aa in length. It contains a 146aa propeptide aa21-166 coupled to a 746aa type I transmembrane mature protein aa 167-913. The mature region possesses a 565aa extracellular domain aa167-731 plus a 160aa cytoplasmic region aa753-913. Consistent with classical cadherins, cadherin-4 contains five cadherin repeats in the extracellular domain aa167-721. There is one potential splice form that shows a 44aa substitution for aa291-913. Over aa21-731, mouse cadherin-4 shares 98% and 93% aa identity with rat and human cadherin-4. | | | Catalog # | C0108-38A | | Applications | Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. | | Recommended Dilution | Western Blot: 1ug/ml | | Immunohistochemistry: 5-15ug/ml | | Optimal dilutions to be determined by the researcher. | | Storage and Stability Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Sheep | | Source | Mouse | | Concentration | ~0.1mg/ml after reconstitution | | Form | Supplied as a lyophilized powder in PBS, trehalose. Reconstitute with sterile PBS to 0.2mg/ml. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Recombinant corresponding to aa21-731 from mouse Cadherin-4 expressed in NS0 cell line. | | Specificity | Recognizes mouse Cadherin-4. Species sequence homology: Recombinant human Cadherin-4 (5%), recombinant mouse Cadherin-2 (5%), recombinant mouse E-Cadherin (<1%). | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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