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You are here:Home » Antibodies » Abs to Cadherin » Anti -Cadherin R (Cadherin 4, Cadherin-4, Retinal Cadherin, CDH4, R-CAD, R-cadherin)

Anti -Cadherin R (Cadherin 4, Cadherin-4, Retinal Cadherin, CDH4, R-CAD, R-cadherin)

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Specifications

Clone Host Grade Applications
Polyclonal Sheep Affinity Purified B IH
Cadherin-4 (also Retinal/R-Cadherin) is a 120kD (100kD predicted) member of the classical cadherin family of molecules. It is expressed on mammary epithelium, olfactory bulb neurons, cerebellar granule cells, vascular smooth muscle, astrocytes and pancreatic B-cells. Cadherin-4 forms both homodimers and heterodimers with N-cadherin. These complexes will oligomerize, providing sources for adhesion and migration. Cadherin-4 also binds to KLRG1 expressed on NK, T and Treg lymphocytes. Mouse cadherin-4 proprecursor is 893aa in length. It contains a 146aa propeptide aa21-166 coupled to a 746aa type I transmembrane mature protein aa 167-913. The mature region possesses a 565aa extracellular domain aa167-731 plus a 160aa cytoplasmic region aa753-913. Consistent with classical cadherins, cadherin-4 contains five cadherin repeats in the extracellular domain aa167-721. There is one potential splice form that shows a 44aa substitution for aa291-913. Over aa21-731, mouse cadherin-4 shares 98% and 93% aa identity with rat and human cadherin-4.
Catalog #C0108-38A
ApplicationsSuitable for use in Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 1ug/ml
Immunohistochemistry: 5-15ug/ml
Optimal dilutions to be determined by the researcher.
Storage and Stability Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostSheep
SourceMouse
Concentration~0.1mg/ml after reconstitution
FormSupplied as a lyophilized powder in PBS, trehalose. Reconstitute with sterile PBS to 0.2mg/ml.
PurityPurified by immunoaffinity chromatography.
ImmunogenRecombinant corresponding to aa21-731 from mouse Cadherin-4 expressed in NS0 cell line.
SpecificityRecognizes mouse Cadherin-4. Species sequence homology: Recombinant human Cadherin-4 (5%), recombinant mouse Cadherin-2 (5%), recombinant mouse E-Cadherin (<1%).
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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