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You are here:Home » Antibodies » Abs to Enzymes, Phosphatase » Anti -Calcineurin A alpha (Protein Phosphatase 2B, A subunit, alpha isoform, CnA alpha )

Anti -Calcineurin A alpha (Protein Phosphatase 2B, A subunit, alpha isoform, CnA alpha )

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
Calcineurin is a serine/threonine protein phosphatase involved in the mediation of signal transduction in a wide variety of cellular responses. Calcineurin has been linked to Pmk1 MAP kinase and PI pathways, as well as to members of the small GTPase Rab/Ypt family and Type II myosin. Furthermore, calcineurin participates in the transduction of extracellular signals to the nucleus by dephosphorylation of members of the NFAT family of transcription factors. These linkages demonstrate calcineurin's multifunctional capabilities in the regulation of calcium signaling. The A alpha form of calcineurin is a major catalytic subunit gene isoform of calcineurin in most tissues that allows differentiation of A alpha from the A beta and A upsilon isoforms.
Catalog #C0114-02A
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1:1000
Optimal dilutions to be determined by the researcher.
Positive ControlMouse brain lysate.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid in PBS 0.1 M Tris-Glycine, pH7.4, 150mM NaCl, 40% gylerol. Contains no preservative.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to human Calcineurin A alpha (KLH).
SpecificityRecognizes the human A alpha. Species crossreactivity
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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