Anti -Calcineurin A (Calcineurin-A, Calcineurin A alpha, CALNA, CALNA1, CALN,
Calmodulin-dependent Calcineurin A Subunit alpha Isoform, CAM-PRP Catalytic Subunit, CCN1,
CNA1, CNA-1, CNA, PPP2B, Protein Phosphatase 3 (formerly 2B) Catalytic Subunit alpha
Isoform
Pricing
For pricing information, USA customers sign in. Outside USA? Please contact your distributor for pricing. Specifications
| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
B IP |
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| Calcineurin is a calcium/calmodulin-dependent serine/threonine protein phosphatase. The active enzyme is a heterodimer consisting of a catalytic A subunit of 61kD and a myristylated regulatory B subunit of 19kD that binds calcium. The catalytic A subunit consists of an amino terminal catalytic domain, followed by calmodulin and B subunit binding sites, and a caboxyl-terminal autoinhibitory domain. Calnineurin is the target of immunosuppressant drugs such as cyclosporin A and FK506. Calcineurin controls the translocation of nuclear factors of activated T cells (NFAT), a family of transcriptional activators that control the expression of cytokine genes essential to immune response, from the cytosol into the nucleus of activated T cells. Calcineurin has been proposed to play an important role in mediating calcium-activated cell death. | | | Catalog # | C0114-07A | | Applications | Suitable for use in Western Blot and Immunoprecipitation. Other applications have not been tested. | | Recommended Dilutions | Western Blot: 1-4 ug/ml | | Immunoprecipitation: 10-20ug/ml | | Optimal dilutions to be determined by the researcher. | | Control Peptide | C0114-07A1 | | Storage and Stability | May be stored at 4°C for short-term only. For long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | ~0.2mg/ml | | Form | Supplied as a liquid in PBS, pH 7.2, 0.5% BSA, 0.01% thimerosal, 30% glycerol. | | Purity | Purified by immunoaffinitiy chromatography. | | Immunogen | Synthetic peptide corresponding to residues surrounding aa267 of human Calcineurin A. | | Specificity | Recognizes human Calcineurin A at ~61kD. A 32kD band can also be detected in human samples, presumably to be the cleavage product of Calcineurin A. Species Crossreactivity: mouse, rat, rabbit, bovine, hamster, dog. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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Download Specifications for Anti -Calcineurin A (Calcineurin-A, Calcineurin A alpha, CALNA, CALNA1, CALN, Calmodulin-dependent Calcineurin A Subunit alpha Isoform, CAM-PRP Catalytic Subunit, CCN1, CNA1, CNA-1, CNA, PPP2B, Protein Phosphatase 3 (formerly 2B) Catalytic Subunit alpha Isoform |
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