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Specifications

Clone Host Grade Applications Monoclonal Rabbit Supernatant IH

Calcitonins (CTs) are a group of polypeptide hormones containing 32aa residues which share an amino terminal ring structure, with cysteines at 1 and 7 linked by a disulfide bridge, as well as a carboxy terminal prolinamide. It is usually synthesized in the parafollicular or C cells in the thyroid gland, and also in a wide variety of other tissues, including the lung and intestinal tract. It plays an active role in calcium homeostasis. A large number of diseases are associated with abnormally increased or decreased levels of calcitonin. Alternative RNA processing of human calcitonin: calcitonin gene-related peptide (CGRP) gene generates two mRNAs encoding the precursors of calcitonin and CGRP. It is used in the treatment of bone loss disorders because it inhibits osteoclast function.
Catalog #	C0115-08Q
Applications	Suitable for use in Immunohistochemistry. Other applications not tested.
Recommended Dilution	Immunohistochemistry (formalin fixed paraffin embedded): 1:100
	Optimal dilutions to be determined by the researcher.
Positive Control	Thyroid or Medullary carcinoma
Storage and Stability	May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
CAS Number	n/a
Clone Type	Monoclonal
Isotype	IgG
Clone No	11E40
Host	Rabbit
Source	Human
Concentration	Not determined.
Form	Supplied as a liquid, 0.05% sodium azide.
Purity	Supernatant
Immunogen	Synthetic human calcitonin 1-32aa peptide. Cellular Localization: Cytoplasmic.
Specificity	Recognizes human Calcitonin. Species Crossreactivity: canine, equine, monkey, mouse, porcine, rat, sheep.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.