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Anti -Calcium and Integrin Binding Protein 1 (SIP2-28, Calmyrin)
Anti -Calcium and Integrin Binding Protein 1 (SIP2-28, Calmyrin)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Purified |
E B |
|
| Calmyrin is identified as a calcium-binding protein with a molecular weight of ~22kD. Calmyrin displays various properties, including myristoylation, membrane-association, and colocalization with presenilin-2 (PS-2). Functionally, like presenilin, calmyrin causes cell death when overexpressed in HeLa cells. Interestingly, calmyrin coexpresses with PS-2, and induces additive effects in apoptosis. These results indicate diverse roles of calmyrin in cell signaling, cell death and Alzheimer disease through the modulation of presenilin function. | | | Catalog # | C0116-05B | | Applications | Suitable for use in ELISA and Western Blot. Other applications have not been tested. | | Recommended Dilution | ELISA: 0.1–1ug/ml | | Western Blot: 1-3ug/ml | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Freeze at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG1 | | Clone No | 6A14 | | Host | Mouse | | Source | Human | | Concentration | 0.5mg/ml | | Form | Supplied as a liquid in PBS, pH 7.4, 0.1% sodium azide. | | Purity | Purified by Protein A chromatography | | Immunogen | Recombinant Calmyrin protein (full length) | | Specificity | Reacts with both overexpressed and endogenous Calmyrin protein. On Western blots, this antibody identifies a band at ~22kD. Reactivity has been confirmed with human HeLa cell lysates. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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