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You are here:Home » Antibodies » Abs to Calmodulin » Anti -CAMK2A (Calcium/Calmodulin-Dependent Protein Kinase (CaM kinase) II Alpha, CAMKA, KIAA0968, CaM Kinase II alpha Subunit, CaM-kinase II alpha Chain; CaMK-II alpha Subunit, Calcium/Calmodulin-Dependent Protein Kinase II Alpha-B Subunit, Calcium/Calmodulin-D

Anti -CAMK2A (Calcium/Calmodulin-Dependent Protein Kinase (CaM kinase) II Alpha, CAMKA,
KIAA0968, CaM Kinase II alpha Subunit, CaM-kinase II alpha Chain; CaMK-II alpha Subunit,
Calcium/Calmodulin-Dependent Protein Kinase II Alpha-B Subunit, Calcium/Calmodulin-D

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Goat Affinity Purified B
CaMKII is an important member of calcium/calmodulin-activated protein kinase family, functioning in neural synaptic stimulation and T-cell receptor signaling. CaMKII has catalytic and regulatory domains. The binding of Ca++/calmodulin to its regulatory domain releases its autoinhibitory effect and activates the kinase. The activated CaMKII further autophosphorylates at Thr286 to render the kinase constitutively active. The threonine phosphorylation state of CaMKII can be regulated through PP1/PKA. PP1 (protein phosphatase 1) dephosphorylates phospho-CaMKII at Thr286. PKA (protein kinase A) prevents this dephosphorylation through its inhibitory effect on PP1.
Catalog #C1035-25B3
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionELISA: 1:64,000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostGoat
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in Tris saline, 0.02% sodium azide, pH7.3, 0.5% BSA.
PurityPurified by affinity chromatography.
ImmunogenSynthetic peptide corresponding to C-PRTAQSEETRVWHR, from the internal region of human Camk2a (NP_057065.2; NP_741960.1).
SpecificityRecognizes human Camk2a. Species crossreactivity
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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