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You are here:Home » Antibodies » Abs to Calnexin » Anti -Calnexin (CANX, CNX, FLJ26570, Histocompatibility Complex Class I Antigen Binding Protein p88, IP90, P90)

Anti -Calnexin (CANX, CNX, FLJ26570, Histocompatibility Complex Class I Antigen Binding
Protein p88, IP90, P90)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Ascites E B IH IF
Calnexin, an abundant ~90kD integral protein of the endoplasmic reticulum, is also referred to as IP90, p88 and p90. It consists of a large 50kD N-terminal calcium-binding luminal domain, a single transmembrane helix and a short acidic cytoplasmic tail. Unlike its ER counterparts which have a KDEL sequence on their C-terminus to ensure ER retention, calnexin has positively charged cytosolic residues that do the same thing. Most ER proteins act as molecular chaperones and participate in the proper folding of polypeptides and their assembly into mulitsubunit proteins. Calnexin together with calreticulin, plays a key role in glycoprotein folding and its control within the ER, by interacting with folding intermediates via their monoglycosylated glycans. Calnexin has also been shown to associate with the major histocompatability complex class I heavy chains, partial complexes of the T cell receptor and B cell membrane immunoglobulin.
Catalog #C1035-26J6
ApplicationsSuitable for use in Immunofluorescence, ELISA, Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionImmunofluorescence: 1:200-1:1000
ELISA: 1:10,000
Western Blot: 1:500-1:2000
Immunohistochemistry (Formalin fixed paraffin embedded): 1:200-1:400
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG2b
Clone No3H4A7
HostMouse
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid, 0.03% sodium azide.
PurityAscites
ImmunogenSynthetic peptide CEAAEERPWLWVVYILTVAL corresponding to human Calnexin conjugated to KLH.
SpecificityRecognizes human CANX.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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