Anti -Calreticulin (CALR, Calregulin, cC1qR, CRP55, CRTC, Endoplasmic Reticulum Resident
Protein 60, ERp60, FLJ26680, grp60, HACBP, Sicca Syndrome Antigen A, SSA, Ro, Autoantigen
Ro)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Ascites |
E B IH IF |
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| Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an aa sequence in the DNA-binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium. The amino terminus of calreticulin interacts with the DNA-binding domain of the glucocorticoid receptor and prevents the receptor from binding to its specific glucocorticoid response element. Calreticulin can inhibit the binding of androgen receptor to its hormone-responsive DNA element and can inhibit androgen receptor and retinoic acid receptor transcriptional activities in vivo, as well as retinoic acid-induced neuronal differentiation. Thus, calreticulin can act as an important modulator of the regulation of gene transcription by nuclear hormone receptors. Systemic lupus erythematosus is associated with increased autoantibody titers against calreticulin but calreticulin is not a Ro/SS-A antigen. Earlier papers referred to calreticulin as an Ro/SS-A antigen but this was later disproven. Increased autoantibody titer against human calreticulin is found in infants with complete congenital heart block of both the IgG and IgM classes. | | | Catalog # | C1036-01Q | | Applications | Suitable for use in Immunofluorescence, ELISA, Western Blot and Immunohistochemistry. Other applications not tested. | | Recommended Dilution | Immunofluorescence: 1:200-1:1000 | | ELISA: 1:10,000 | | Western Blot: 1:500-1:2000 | | Immunohistochemistry (Formalin fixed paraffin embedded): 1:200 | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG2a | | Clone No | 1G6A7 | | Host | Mouse | | Source | Human | | Concentration | Not determined | | Form | Supplied as a liquid. | | Purity | Ascites | | Immunogen | Synthetic peptide corresponding to aa EEEDVPGQAKDELC of human Calreticulin conjugated to KLH. | | Specificity | Recognizes human CALR. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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Download Specifications for Anti -Calreticulin (CALR, Calregulin, cC1qR, CRP55, CRTC, Endoplasmic Reticulum Resident Protein 60, ERp60, FLJ26680, grp60, HACBP, Sicca Syndrome Antigen A, SSA, Ro, Autoantigen Ro) |
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