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You are here:Home » Antibodies » Abs to Calretinin » Anti -Calretinin (CR, Calbindin 2, Calb2)

Anti -Calretinin (CR, Calbindin 2, Calb2)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Serum IH
Calretinin is an intracellular calcium-binding protein belonging to the troponin C superfamily. The sequence of the calretinin cDNA revealed an open reading frame of 271 codons coding for a protein of 31 520 Da, and sharing 58% identical residues with Human calbindin D28k. It contains five presumably active and one presumably inactive calcium-binding domain. The protein is highly conserved in evolution and is expressed in the brain mianly in the auditory neurons. There are two additional forms of alternatively spliced calbindin 2 mRNAs encoding C-terminally truncated proteins. Exon 7 can splice to exon 9, resulting in a frame shift and a translational stop at the second codon of exon 9, and encoding calretinin-20k. Exon 7 can also splice to exon 10, resulting in a frame shift and a translational stop at codon 15 of exon 10, and encoding calretinin-22k. The truncated proteins are able to bind calcium. It is mapped to 16q22.2 region of Human chromosome.
Catalog #C1036-01V
ApplicationsSuitable for use in Immunohistochemistry. Other applications not tested.
Recommended DilutionImmunohistochemistry (paraffin): 1:50-1:100
Optimal dilutions to be determined by the researcher.
Positive ControlMesothelioma
Cellular Localization
Cytoplasmic
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceMouse
ConcentrationNot determined
FormSupplied as a liquid in 0.05% sodium azide.
PuritySerum
ImmunogenRecombinant full length mouse Calretinin protein.
SpecificityRecognizes human Calretinin. Species Crossreactivity: mouse and rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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