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You are here:Home » Molecular Biology » MB-Binding Proteins » Calsequestrin-2 (CASQ2, CSQ, Calsequestrin cardiac muscle isoform)

Calsequestrin-2 (CASQ2, CSQ, Calsequestrin cardiac muscle isoform)

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Specifications

Calsequestrin is the major calcium storage protein of the sarcoplasmic reticulum. Intraluminar Ca2+ binds to calsequestrin during diastole to prevent Ca2+ precipitation and to lower its free ionic concentration to facilitate efficient storage. During systole, Calsequestrin coordinately releases ~40-50 Ca2+ ions per molecule for each contraction-relaxation cycle by an uncertain mechanism. Calsequestrin has been shown to be of major importance in the regulation of cardiac excitation-contraction coupling.
Catalog #C1036-05G
ApplicationsSuitable for use in Western Blot, Absorption and Immunohistochemistry. Other applications not tested.
Recommended DilutionsOptimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
SourceCanine heart
Purity90% by SDS-PAGE
FormSupplied as a lyophilized powder from 10mM Tris-HCl, 1mM EGTA. Reconstitute in sterile dH20 to 0.1mg/ml.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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