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Calsequestrin-2 (CASQ2, CSQ, Calsequestrin cardiac muscle isoform)
Calsequestrin-2 (CASQ2, CSQ, Calsequestrin cardiac muscle isoform)
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| Calsequestrin is the major calcium storage protein of the sarcoplasmic reticulum. Intraluminar Ca2+ binds to calsequestrin during diastole to prevent Ca2+ precipitation and to lower its free ionic concentration to facilitate efficient storage. During systole, Calsequestrin coordinately releases ~40-50 Ca2+ ions per molecule for each contraction-relaxation cycle by an uncertain mechanism. Calsequestrin has been shown to be of major importance in the regulation of cardiac excitation-contraction coupling. | | | Catalog # | C1036-05G | | Applications | Suitable for use in Western Blot, Absorption and Immunohistochemistry. Other applications not tested. | | Recommended Dilutions | Optimal dilutions to be determined by the researcher. | | Storage and Stability | Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | Source | Canine heart | | Purity | 90% by SDS-PAGE | | Form | Supplied as a lyophilized powder from 10mM Tris-HCl, 1mM EGTA. Reconstitute in sterile dH20 to 0.1mg/ml. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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