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You are here:Home » Antibodies » Abs to Neuroscience » Anti -Calsyntenin-2 (Calsyntenin 2, Alcadein-gamma, Alc-gamma, CLSTN2, CS2)

Anti -Calsyntenin-2 (Calsyntenin 2, Alcadein-gamma, Alc-gamma, CLSTN2, CS2)

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Specifications

Clone Host Grade Applications
Polyclonal Sheep Affinity Purified IH
Calsyntenin-2 (CS-2) is a 120-135kD member of the Alcadein family of molecules. It is expressed in the ER/Golgi, and the plasma membranes of almost all neurons. It is a calcium-binding protein that interacts with APP and X11L. In this regard, it appears to regulate APP cleavage and gene activation, and likely impacts post-synaptic signaling. Notably, when cleaved in a manner similar to APP, its intracellular fragment antagonizes AICD gene activation. Mature human CS-2 is a 935aa type I transmembrane protein. It contains two cadherin domains aa44-280 in its extracellular region aa21-831 and a 103aa cytoplasmic tail. Proteolytic cleavage by ADAM10 occurs between His803 and Leu804 to generate a 105-110kD extracellular fragment. Additional processing of the transmembrane fragment by g-secretase creates a 3kD fragment aa804-834 plus a 25kD cytoplasmic protein. Potential isoform variants show a premature truncation after Gln608, and the use of an alternative start site at Met409. Over aa21-834, human CS-2 shares 95aa identity with mouse CST-2.
Catalog #C1036-36
ApplicationsSuitable for use in Immunohistochemistry. Other applications not tested.
Recommended DilutionImmunohistochemistry: 5-15ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostSheep
SourceHuman
ConcentrationNot determined
FormSupplied as a lyophilized powder in PBS, trehalose. Reconstitute with sterile PBS to 200ug/ml.
PurityPurified by immunoaffinity chromatography.
ImmunogenRecombinant corresponding to aa21-834 from Calsyntenin-2 expressed in NSO cells (Q9H4D0).
SpecificityRecognizes human Calsyntenin-2. Species sequence homology: human Calsyntenin-1 and Calsyntenin-3 (1%).
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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