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You are here:Home » Molecular Biology » MB-Protein Kinase Inhibitors » Canertinib, Dihydrochloride (N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[3-(4-morpholinyl)propoxy]-6-quinazolinyl]-2-propenamide Dihydrochloride, CI-1033, PD183805)

Canertinib, Dihydrochloride
(N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[3-(4-morpholinyl)propoxy]-6-quinazolinyl]-2-prop
enamide Dihydrochloride, CI-1033, PD183805)

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Specifications

Canertinib (CI-1033, PD 183805) is a pan-erbB tyrosine kinase inhibitor. It selectively inhibits erbB1 (epidermal growth factor receptor), erbB2, erbB3, and erbB4 without blocking tyrosine kinase activity of many other receptors such as platelet-derived growth factor receptor, fibroblast growth factor receptor, and insulin receptor.
Catalog #C1075-25
SolubilitySoluble in DMSO at 100mg/ml; soluble in ethanol at 1mg/ml with warming; soluble in water at 10mg/ml with warming; buffers, serum, or other additives may increase or decrease the aqueous solubility. Compound is somewhat unstable in HPLC sample solution at room temperature.
Storage and StabilityMay be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
CAS Number289499-45-2
Molecular FormulaC24H25ClFN5O32HCl
Molecular Weight558.86
Purity~99%
FormSupplied as an off-white to pale green powder.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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