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You are here:Home » Biochemicals » Biochem-Drugs/Analogues » Capecitabine (5-Deoxy-5-fluoro-N-[(pentyloxy)carbonyl]cytidine, Ro-9-1978, Xeloda)

Capecitabine (5-Deoxy-5-fluoro-N-[(pentyloxy)carbonyl]cytidine, Ro-9-1978, Xeloda)


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Capecitabine is a pre-prodrug of 5-fluorouracil (5-FU). After oral uptake, capecitabine is first metabolized to 5'-deoxy-5-fluorocytidine (5'-DFCR), which happens mainly in the liver by carboxyl-esterase. The metabolite is converted to 5'-deoxy-5-fluoro-uridine (5'-DFUR) by cytidine deaminase in liver and tumor tissue. Then 5'-DFUR is converted to 5-FU intracellularly by thymidine phosphorylase, which is often expressed in tumor tissue.
Catalog #C1077-05B
SolubilitySoluble in DMSO at 100mg/ml; soluble in ethanol at 12.5mg/ml with slight warming; soluble in water at 2mg/ml with slight warming; buffers, serum, or other additives may increase or decrease the aqueous solubility.
Storage and StabilityMay be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
CAS Number154361-50-9
Molecular FormulaC15H22FN3O6
Molecular Weight359.35
FormSupplied as a white to off-white powder.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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