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You are here:Home » Antibodies » Abs to Receptors, Estrogen » Anti -Caper (RNPC2, RNA-binding region containing protein 2, Coactivator of activating protein-1 and estrogen receptors, HCC1, Hepatocellular carcinoma protein 1, Splicing factor CC1.3, Splicing factor CC1.4)

Anti -Caper (RNPC2, RNA-binding region containing protein 2, Coactivator of activating
protein-1 and estrogen receptors, HCC1, Hepatocellular carcinoma protein 1, Splicing
factor CC1.3, Splicing factor CC1.4)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IP
Heterogeneous nuclear ribonucleoproteins (hnRNP) bind to nascent RNA polymerase II transcripts and are involved in transcript-specific packaging as well as alternative splicing of pre-mRNAs. hnRNPs also appear to influence mRNA metabolism and transport. In vivo, the M proteins bind to mRNA, and in vitro they bind avidly to poly(G) and poly(U) homopolymers. Four different isoforms of hnRNP are produced by alternative splicing: M1, M2, M3, and M4. Ongoing studies have theorized that hnRNPs may cause certain genetic diseases such as myotonic dystrophy, which is the most common form of adult muscular dystrophy. The identification of hnRNPs may therefore be important to determining the cause and cure for genetic diseases.
Catalog #C1077-10B
Transcriptional coactivators either bridge transcription factors and the components of the basal transcription apparatus and/or remodel the chromatin structures. CAPER (coactivator of activating protein-1 (AP-1) and estrogen receptors (ERs)) may represent a selective transcriptional coactivator molecule that plays a pivotal role for the function of AP-1 and ERs in vivo in conjunction with the general coactivator ASC-2.
ApplicationsSuitable for use in Western Blot and Immunoprecipitation. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
HostRabbit
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid
PurityPurified by immunoaffinity chromatography.
ImmunogenThe epitope recognized maps to a region between residues 325-375 of human Caper, Coactivator of activating protein-1 and estrogen receptors using the SwissProt entry Q14498 (GeneID 9584).
.
SpecificityThis antibody is specific for human Caper. Species Crossreactivity: reacts with human protein. Other species have not been tested. Reactivity with mouse Caper is likely owing to conservation between the mouse sequence and the peptide used for this antibody production.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesRNPC2, RNA-binding region containing protein 2, Coactivator of activating protein-1 and estrogen receptors, HCC1, Hepatocellular carcinoma protein 1, Splicing factor CC1.3, Splicing factor CC1.4


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