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You are here:Home » Antibodies » Abs to Ion Channel » Anti -Capsaicin Receptor (Osm-9-like TRP Channel 1, OTRPC1, Transient Receptor Potential Cation Channel Subfamily V Member 1, TrpV1, Vanilloid Receptor 1, VR1, Vanilloid Receptor Type 1-like, Vr1l, Vr1l1, VR.5'sv)

Anti -Capsaicin Receptor (Osm-9-like TRP Channel 1, OTRPC1, Transient Receptor Potential
Cation Channel Subfamily V Member 1, TrpV1, Vanilloid Receptor 1, VR1, Vanilloid Receptor
Type 1-like, Vr1l, Vr1l1, VR.5'sv)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified IH
The capsaicin receptor is involved in the detection of noxious chemical and thermal stimuli. It seems to mediate proton influx and to be involved in intracellular acidosis in nociceptive neurons. It may also mediate inflammatory pain and hyperalgesia. It is activated by vanilloids, such as capsaicin, and temperatures higher than 42ºC. The capsaicin receptor is probably as homotetramer but may also form a heteromeric channel with TRPV3. It interacts with calmodulin, PRKCM and CSK and with PRKCG and NTRK1. There are 3 named isoforms produced by alternative splicing. The capsaicin receptor is a transmembrane protein that localises to the cell membrane. It is predominantly expressed in trigeminal and dorsal root sensory ganglia. Isoform 1 and 3 are also expressed in brain and peripheral blood mononuclear cells.
Catalog #C1078-01R
Applications
Suitable for use in Immunohistochemistry. Other applications not tested.
Recommended DilutionImmunohistochemistry: 0.5-1ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
Clone No10g9
HostMouse
SourceRat
Concentration~1mg/ml (after reconstitution)
FormSupplied as a lyophilized powder. Reconstitute with 100ul sterile ddH2O.
PurityPurified by Protein G affinity chromatography.
ImmunogenSynthetic peptide corresponding to aa819-838, CGSLKPEDAEVFKDSMVPGEK to a part of rat protein, conjugated to KLH. Species Sequence Homology: mouse.
SpecificityRecognizes rat Capsaicin Receptor. Species Crossreactivity: guinea pig.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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