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You are here:Home » Antibodies » Abs to GTPase, Rab, Ras, Rho Proteins » Anti -Carabin (FLJ00332, MGC46488, TBC1 Domain Family Member 10C, TBC1D10C)

Anti -Carabin (FLJ00332, MGC46488, TBC1 Domain Family Member 10C, TBC1D10C)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
Carabin is a 50kD protein belonging to the TBC1 domain family of proteins. Carabin differs from other members of the TBC1 domain protein family, which appear to play a role in the regulation of cell growth and differentiation. Studies demonstrate that Carabin is part of a negative regulatory loop for the intracellular TCR signalling pathway and acts as an inhibitor of the Ras signalling pathway. Carabin is also believed to mediate crosstalk between calcineurin and Ras. Carabin is most abundantly expressed in spleen and peripheral blood leucocytes.
Catalog #C1079-15
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1-2ug/ml
Optimal dilutions to be determined by the researcher.
Positive ControlHuman spleen cell lysates
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, 0.02% sodium azide.
PurityPurified by affinity chromatography.
ImmunogenSynthetic peptide corresponding to a 17aa from near the amino terminus of human Carabin.
SpecificityRecognizes human Carabin at ~55kD. Does not crossreact with either TBC1D10A or TBC1D10B. Species Crossreactivity: mouse
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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